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Jul012015

China Pushing Frontiers of Medical Research

Wednesday, July 1, 2015 at 11:22AM

Cutting-edge medical research in China is promising to boost human health and development. Futuristic science is being conducted on a large scale and it is hoped this will increase the pace of discovery.

Around the world, rapid progress is being made in understanding the role played by genes and how they affect our overall health and susceptibility to diseases. Other developments are leading to the possibility of creating replacements for organs and other body parts that have been damaged through accidents, disease or genetic faults – without the need for organ donors.

Medical advances straight out of science fiction could be closer than many believe. By using machines and gene therapy, radical new methods will emerge to deal with damage done to human bodies as a result of accidents or disease. These solutions will become, in time, quicker, smaller and cheaper and will be available to more and more countries. They will spread outwards around the global South just as mobile phones and computing electronics have done.

In China, the government is investing heavily in this cutting-edge research and attracting investment and projects from around the world to increase the pace of progress in these areas.

In September 2013, Reuters reported that a 22-year-old man named Xiaolian in Fuzhou, China had a new nose grown on his forehead to replace his original nose that had been damaged in a car accident. Conventional reconstructive surgery was not possible, so this radical new approach was taken.

The advantages of growing a nose on the patient include a reduced chance of rejection by the body when the new organ is attached. Transplants of body parts from other people come with a high risk of rejection and require many drugs to prevent it. Using skin near where the transplant is to take place, on the face, improves the chances of success and the blood vessels in the forehead offer nourishment to grow the new nose.

The procedure works like this: tissue expanders are placed on the patient’s forehead. As it grows, the doctors cut the mass of tissue into the shape of a nose and cartilage from the patient’s ribs is placed inside to give the nose shape. The new proboscis (http://en.wikipedia.org/wiki/Proboscis) grows under the skin until it is the right size and then transplanted onto the patient’s face where their old nose was.

Many believe this is just the beginning and that in the future replacement organs will be also grown in a lab. And this is where the new medical technology of 3D bioprinting comes into play.

3D printing machines (http://www.k8200.eu/), or fabricators, can create 3D objects based on a design sent from a computer. This concept is now also being applied to biological materials with 3D bioprinters.

Hangzhou Dianzi University of Electronic Science and Technology (hdu.edu.cn) in China launched the Regenovo 3D Bio-printer in August 2013. It prints living tissue and looks like a silver metal frame with various nozzles situated above a platform for printing the tissue. Its makers claim it can print a liver in 40 minutes to an hour or an ear in 50 minutes.

A sheet of hydrogel is placed on the platform and then the bioprinter deposits cells into the hydrogel. As the process is repeated over and over again, layer after layer, a 3D biological structure emerges.

Unique Technology (sinounic.com) in Qingdao, Shandong province has also launched a 3D printer called “Re-human”. It is capable of printing at 15 microns and can operate in temperatures of between 0 and 300 degrees Celsius. Scientists there are working on clinical trials of 3D-printed tissue scaffolds and bones.

China is very advanced in the development of 3D manufacturing technology, and is home to the world’s largest 3D printers, developed by Dalian University of Technology (http://www.dlut.edu.cn/en/). Another Chinese company pioneering this technology is Shaanxi Hengtong Intelligent Machines (http://www.china-rpm.com/english/), which sells various laser-using rapid prototyping machines and 3D machines.

Around the world, bioprinting is currently being pioneered for printing heart valves, ears, artificial bones, joints, vascular tubes, and skin for grafts.

The number of scientific papers mentioning bioprinting tripled between 2008 and 2011 according to Popular Science. But why is this happening? Three things are occurring at once: sophisticated 3D printers are now available, there are significant advances in regenerative medicine, and CAD (computer-aided design) (http://en.wikipedia.org/wiki/Computer-aided_design) software continues to become more advanced.

San Diego, California’s Organovo (organovo.com), a company that designs and creates functional human tissues using 3D bioprinting, has big ambitions for the technology.

“Getting to a whole organ-in-a-box that’s plug-and-play and ready to go, I believe that could happen in my lifetime,” its chief technology officer, Sharon Presnell, told Popular Science.

In the field of gene science, China is also investing significant resources to make rapid progress. China is working to make its genetic research industry into one of the country’s pillar industries.

Beijing Genomics Institute (BGI) (http://www.genomics.cn/en/index) is the world’s largest genome-mapping institute, with more than 1,000 biological analysis devices working with top-of-the-line genome-sequencing machines. What makes BGI different is scale: it can handle data in vast quantities and industrialize its research, according to China Daily.

The China National Genebank in Shenzhen (http://www.nationalgenebank.org/en/index.html), associated with BGI and its Cognitive Genetics Project, is one of the largest gene banks in the world. It has collected the DNA (http://www.biologycorner.com/bio1/DNA.html) samples of some of the world’s smartest people to sequence their genomes and work out which alleles (http://www.sciencedaily.com/articles/a/allele.htm) determine human intelligence.

But what will they do with this information? By doing embryo screening, it will be possible to pick the brightest zygote (http://en.wikipedia.org/wiki/Zygote) and ensure an entire generation’s intelligence is increased by five to 15 IQ (intelligence quotient) points. This could have a significant impact on the country’s economic performance, the researchers believe, and help in the country making more rapid economic and development gains. This line of research is also seen globally as being fraught with ethical dilemmas and is controversial.

But the Chinese researchers believe the country’s economic productivity, business success, international competitiveness and the amount of innovation in the economy could all increase with an IQ boost.

The eggs are fertilized in the lab with the father’s sperm and the embryos are tested until they find the smartest one.

Embryo analysis could take place on a large scale in a few years. But it is not just better brains that are possible with this technique: choices can be made about hair and eye colors, and physical attributes such as body shape.

This level of research is benefiting from vast investments in higher education in China.

And it isn’t just human beings receiving the vast investment in gene research.

To help agriculture and agribusiness, the National Center for Gene Research (NCGR) (ncgr.ac.cn) is mapping and sequencing the rice genome, and genomes of other organisms. Since 2007, it has been using the latest generation sequencing technology to map the rice genome to identify common genetic factors. It has 50 million base pairs of rice genomic DNA sequences in its public database. It is hoped this will lead to more robust rice varieties that can withstand disease and climate fluctuations and help meet the food needs of a growing global population.

By David South, Development Challenges, South-South Solutions

Published: November 2013

Development Challenges, South-South Solutions was launched as an e-newsletter in 2006 by UNDP's South-South Cooperation Unit (now the United Nations Office for South-South Cooperation) based in New York, USA. It led on profiling the rise of the global South as an economic powerhouse and was one of the first regular publications to champion the global South's innovators, entrepreneurs, and pioneers. It tracked the key trends that are now so profoundly reshaping how development is seen and done. This includes the rapid take-up of mobile phones and information technology in the global South (as profiled in the first issue of magazine Southern Innovator), the move to becoming a majority urban world, a growing global innovator culture, and the plethora of solutions being developed in the global South to tackle its problems and improve living conditions and boost human development. The success of the e-newsletter led to the launch of the magazine Southern Innovator.

Follow @SouthSouth1

Google Books: https://books.google.co.uk/books?id=2fdcAwAAQBAJ&dq=development+challenges+november+2013&source=gbs_navlinks_s

Slideshare: http://www.slideshare.net/DavidSouth1/development-challenges-november-2013-issue

Southern Innovator Issue 1: https://books.google.co.uk/books?id=Q1O54YSE2BgC&dq=southern+innovator&source=gbs_navlinks_s

Southern Innovator Issue 2: https://books.google.co.uk/books?id=Ty0N969dcssC&dq=southern+innovator&source=gbs_navlinks_s

Southern Innovator Issue 3: https://books.google.co.uk/books?id=AQNt4YmhZagC&dq=southern+innovator&source=gbs_navlinks_s

Southern Innovator Issue 4: https://books.google.co.uk/books?id=9T_n2tA7l4EC&dq=southern+innovator&source=gbs_navlinks_s

Southern Innovator Issue 5: https://books.google.co.uk/books?id=6ILdAgAAQBAJ&dq=southern+innovator&source=gbs_navlinks_s

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David South |

Maker Faire and the R & D Rise in the South

Tuesday, June 23, 2015 at 9:43AM

The majority of the world’s research and development (R & D) in science and technology is now shifting to the global South. Powerhouses like China boast vast numbers of published papers in peer-reviewed journals and hefty cash inputs into research and development.

China increased its R & D spending in 2009 to US $25.7 billion, a 25.6 percent increase over 2008, according to Du Zhanyuan, vice minister of the Ministry of Science and Technology. China is rapidly closing the science funding gap with Japan: in 2009 it allotted US $37.1 billion for R & D.

The times have never been better for those with new ideas in the global South.

And it’s not just big companies that are involved. There is R & D going on at ground level as well. African inventors, innovators and creatives met in Nairobi, Kenya in August as part of the Maker Faire Africa 2010 (http://makerfaireafrica.com). This is research and development on a shoestring, and done in a very practical, problem-solving way. While Africa’s inventors and innovators lack the big budgets of other economies, they are not short on ideas and drive.

The Maker Faire Africa is a family-friendly gathering where the inventors can showcase their work and connect with others. It is a mix of workshops, tips on business skills, awards and a party.

The global economy thrives on innovation and so-called ‘creative destruction’ – as economist Joseph Schumpeter called it (http://en.wikipedia.org/wiki/Creative_destruction) – that takes place as out-of-date technologies and ways of doing are surpassed by better ideas and more efficient methods. The power to innovate is the deciding factor for sustained economic growth.

The philosophy behind Maker Faire Africa 2010 – the brainchild of ‘venture catalyst’ and entrepreneur Emeka Okafor (http://timbuktuchronicles.blogspot.com) – is to prove that innovation doesn’t just happen with computers.

As its website says, “The aim of a Maker Faire-like event is to create a space on the continent where Afrigadget-type innovations (http://www.afrigadget.com), inventions and initiatives can be sought, identified, brought to life, supported, amplified, propagated, etc.”

Maker Faire Africa is working with research organizations like Ghana’s Ashesi University (http://www.ashesi.edu.gh/index.html) and Kwame Nkrumah University of Science and Technology (http://www.knust.edu.gh/pages) “to sharpen focus on locally-generated, bottom-up prototypes of technologies that solve immediate challenges to development.”

In the end, the goal of engaging all this creative and inventive energy is to spur Africans towards building “a manufacturing base that supplies innovative products in response to market needs.”

This initiative stands out in several ways: it is truly inspiring, it gets to the core of how wealth is created, and helps build communities of innovators and inventors to tackle the problems facing Africa – and humanity.

“We have a broader variety of makers this time around,” says Emeka Okafor of the 2010 Maker Faire. He notes makers are bringing more complex systems to the Faire, rather than just single devices. And that they “have more makers who are actually from the region.”

“Maker Faire Africa is essentially a platform whereby innovators, inventers, creative types, across all disciplines, share ideas, showcase their products, interact with attendees and other makers,” he continues. They “begin the process of building what we think is an essential community of what I like to term the productive class. That is essentially where we see ourselves playing a key role. A productive class whose foundation is laid upon building problem-solving systems.”

Okafor believes Africa just doesn’t “have enough wealth creation as we should.”

“We have things backwards. … One of the essential steps is that you had productive systems that allowed those countries (Asia and Europe) to create wealth. And they had to draw those resources from within.

“We see Maker Fair Africa celebrating resources that we already have, with knowledge from within and outside.

“In many ways the Makers as we see them, epitomise the very sense of problem-solving that as a society acquires more of it, it begins to deal with its challenges very differently. And not look elsewhere in terms of dealing with its challenges. We want to make our Makers sexy, we want to make inventors sexy, innovators celebrities.”

Some of the inspiring inventors from this year’s Faire include Norbert Okec from Uganda. His prototype for a solar powered street lighting system comes straight from his frustration with the traffic lights of Kampala, Uganda. Many don’t work and so he has developed a prototype solar-powered traffic light using a mix of recycled local parts and some LEDs (http://en.wikipedia.org/wiki/Light-emitting_diode) brought by a friend from China.

He hopes to produce an e-book on his invention to share with other inventors. He was joined by fellow inventors working on a dashboard for managing wireless networks, how to recycle plastic parts, solar-power torches, water and sanitation products, junk art, community cookers, sculptures, eye glasses, bicycles, and an automatic lighting system for homes.

Okafor is a passionate advocate of the Maker philosophy and how it changes the game: “…building is equivalent to making and making is a joyful thing, it is an interesting thing. It is a very satisfactory thing. It is not work. Most of the individuals around here have the biggest smiles on their faces. They don’t see what they are doing as work.

“The fact they are sitting next to other people like them if anything is one of the biggest take-aways for them. Because for some of them they were toiling away on their own. Now they see others like them. And they realise they aren’t crazy.

“When you build a community and the community begins to get stronger and sustain itself, all the other things come naturally: businesses get formed, partnerships happen: and then everything else people look for first…actually begins to happen.”

And Africa’s future prosperity is what is at stake at the Faire: “There is a market for the products. And we believe as more individuals – Africans and otherwise – come into contact with what is on display, they will come to see their own societies differently. ”